دراسة مستوى عامل نمو الطبقة المبطنة للأوعية الدموية في بول مرضى الاعتلال الكلوي السكري

Rania Al-Khodary Al-Sayed Ata  "A Study of Urinary Vascular Endothelial Growth Factor (VEGF) in Diabetic Nerphropathy.

                                                "Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), is a term used to describe a family of potent multifactorial cytokines. VEGF is considered to be an important mediator in the pathogenesis of endothelial dysfunction in diabetes such as increased endothelial permeability to macromolecules and endothelial proliferation which might be involved in the pathogenesis of microvascular complications of diabetes mellitus as diabetic nephropathy.

The aim of the work is to study the possible changes in the level of urinary VEGF in patients with different stages of diabetic nephropathy and the possible use of urinary VEGF as a marker for the progression of diabetic nephropathy.

Our study was conducted on 55 subjects subdivided into 4 groups:

Group 1:              Included 15 patients with type 2 DM with normoalbuminuria

Group 2: Included 15 patients with type 2 DM with microalbuminuria

Group 3: Included 15 patients with type 2 DM with macroalbuminuria

Group   4:  Included 10 non diabetic healthy subjects as a control group.

They were subjected to full history and thorough clinical examination.They were also subjected to laboratory investigations including; fasting and post prandial blood glucose, glycated haemoglobin(HbA1C), renal function tests(i.e blood urea and serum creatinine), urinary albumin/creatinine ratio (Alb/Cr ratio), urinary VEGF by ELISA, and plasma VEGF by ELISA in some patients."